MLK4 Antibody

• Background:

  Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30% of colorectal cancer contain at least one mutation in the tyrosine kinases; sampling of colorect cancer cells suggest an important role of MLK4 in this process.

• NCBI Gene ID:

  84451

• Swiss Prot:

  Q5TCX8

• Accession Number:

  Q5TCX8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MLK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human MLK4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  114 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MLK4

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase MLK4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gregory, S.G., Nature 441 (7091), 315-321 (2006)

• Other Product Names:

  Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, MLK4 {ECO:0000303|Ref1}

• Tested Applications:

  WB, IHC-P

• Protein ID:

  71153820

• Physical Properties:

  Liquid