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COT Antibody

CAT: 0223-63-306Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-306Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COT, a member of the MAPKKK subfamily of Ser/Thr protein kinases, is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
NCBI Gene ID
1326
Swiss Prot
P41279
Accession Number
P41279
Host
Rabbit
Reactivity
Human
Immunogen
This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
MAP3K8
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 8
NCBI Organism
Homo sapiens
Background Reference 01
Sanchez-Gongora, E., et al., J. Biol. Chem. 275 (40) :31379-31386 (2000) .
Background Reference 02
Aoki, M., et al., J. Biol. Chem. 268 (30) :22723-22732 (1993) .
Background Reference 03
Chan, A.M., et al., Oncogene 8 (5) :1329-1333 (1993) .
Background Reference 04
Miyoshi, J., et al., Mol. Cell. Biol. 11 (8) :4088-4096 (1991) .
Other Product Names
Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2, MAP3K8, COT, ESTF
Tested Applications
WB, IHC-P
Protein ID
50403742
Physical Properties
Liquid

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