PKN beta Antibody

• Background:

  PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA) . PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

• NCBI Gene ID:

  29941

• Swiss Prot:

  Q6P5Z2

• Accession Number:

  Q6P5Z2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  99 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PKN3

• NCBI Official Name:

  Serine/threonine-protein kinase N3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oishi, K., et al., Biochem. Biophys. Res. Commun. 261 (3) :808-814 (1999) .

• Other Product Names:

  Serine/threonine-protein kinase N3, Protein kinase PKN-beta, Protein-kinase C-related kinase 3, PKN3, PKNBETA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74749130

• Physical Properties:

  Liquid