PKD2 Antibody

• Background:

  Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.

• NCBI Gene ID:

  5311

• Swiss Prot:

  Q13563

• Accession Number:

  Q13563

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 937-968 amino acids from the C-terminal region of human PKD2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  110 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PKD2

• NCBI Official Name:

  Polycystin-2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  116242717

• Physical Properties:

  Liquid