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MEKK1 Antibody

CAT: 0223-63-282Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-282Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK) . MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
NCBI Gene ID
4214
Swiss Prot
Q13233
Accession Number
Q13233
Host
Rabbit
Reactivity
Human
Immunogen
This MEKK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1145-1176 amino acids from the C-terminal region of human MEKK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
164 kDa
Fragment
Rabbit Ig
Symbol
MAP3K1
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Xia, Y., et al., Genes Dev. 12 (21) :3369-3381 (1998) .
Background Reference 02
Vinik, B.S., et al., Mamm. Genome 6 (11) :782-783 (1995) .
Other Product Names
Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1
Tested Applications
WB, IHC-P
Protein ID
218512139
Physical Properties
Liquid

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