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GCK Antibody

CAT: 0223-63-280Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-280Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2) ; mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) .
NCBI Gene ID
2645
Swiss Prot
P35557
Accession Number
P35557
Host
Rabbit
Reactivity
Human
Immunogen
This GCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 403-433 amino acids from the C-terminal region of human GCK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Symbol
GCK
NCBI Official Name
Glucokinase
NCBI Organism
Homo sapiens
Background Reference 01
Gloyn, A.L., et al., Diabetes 52 (9) :2433-2440 (2003) .
Background Reference 02
Pruhova, S., et al., Diabetologia 46 (2) :291-295 (2003) .
Background Reference 03
Rizzo, M.A., et al., J. Biol. Chem. 277 (37) :34168-34175 (2002) .
Background Reference 04
Cao, H., et al., Hum. Mutat. 20 (6) :478-479 (2002) .
Other Product Names
Glucokinase, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D, GCK
Tested Applications
WB, IHC-P
Protein ID
547696
Physical Properties
Liquid

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