BCHE Antibody

• Background:

  Mutant proteins of BCHE are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

• NCBI Gene ID:

  590

• Swiss Prot:

  P06276

• Accession Number:

  P06276

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BCHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-415 amino acids from the Central region of human BCHE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  68 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BCHE

• NCBI Official Name:

  Cholinesterase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Primo-Parmo S.L., Bartels C.F.Am. J. Hum. Genet. 58:52-64 (1996)

• Background Reference 02:

  Primo-Parmo S.L., Lightstone H.Pharmacogenetics 7:27-34 (1997)

• Background Reference 03:

  Yen T., Nightingale B.N.Clin. Chem. 49:1297-1308 (2003)

• Other Product Names:

  Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase, BCHE, CHE1

• Tested Applications:

  WB

• Protein ID:

  116353

• Physical Properties:

  Liquid