Transglutaminase Antibody

• Background:

  Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It has been identified as the autoantigen implicated in celiac disease.

• NCBI Gene ID:

  7052

• Swiss Prot:

  P21980

• Accession Number:

  P21980

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Transglutaminase (TGM2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the Central region of human Transglutaminase (TGM2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  77 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TGM2

• NCBI Official Name:

  Protein-glutamine gamma-glutamyltransferase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Porzio, O., Hum. Mutat. 28 (11), 1150 (2007)

• Background Reference 02:

  Parsons, A.C., AmDermatopathol 29 (5), 433-436 (2007)

• Other Product Names:

  Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG (C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  20141877

• Physical Properties:

  Liquid