ACE Antibody

• Background:

  ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.

• NCBI Gene ID:

  1636

• Swiss Prot:

  P12821

• Accession Number:

  P12821

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ACE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1274-1306 amino acids from the C-terminal region of human ACE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  150 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ACE

• NCBI Official Name:

  Angiotensin-converting enzyme

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Du Cheyron, D., Crit. Care Med. 36 (12), 3178-3183 (2008)

• Background Reference 02:

  Pang, S., Biochem. J. 358 (PT 1), 185-192 (2001)

• Background Reference 03:

  Woodman, Z.L., Biochem. J. 347 PT 3, 711-718 (2000)

• Other Product Names:

  Angiotensin-converting enzyme, ACE, 321-, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1

• Tested Applications:

  WB

• Protein ID:

  113045

• Physical Properties:

  Liquid