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SMAD4 Antibody

CAT: 0223-63-182Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-182Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SMAD4 is the common SMAD (co-SMAD) mediator of signal transduction by TGF-beta (transforming growth factor) . It promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. It may act as a tumor suppressor.
NCBI Gene ID
4089
Swiss Prot
Q13485
Accession Number
Q13485
Host
Rabbit
Reactivity
Human
Immunogen
This SMAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from human SMAD4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
SMAD4
NCBI Official Name
Mothers against decapentaplegic homolog 4
NCBI Organism
Homo sapiens
Background Reference 01
Sekiya, T., et al., Biochem. Biophys. Res. Commun. 320 (3) :680-684 (2004) .
Background Reference 02
Horvath, L.G., et al., Prostate 59 (3) :234-242 (2004) .
Background Reference 03
Li, L., et al., Mol. Cell. Biol. 24 (2) :856-864 (2004) .
Background Reference 04
Wan, M., et al., J. Biol. Chem. 279 (15) :14484-14487 (2004) .
Other Product Names
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4
Tested Applications
WB, IF
Protein ID
13959561
Physical Properties
Liquid

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GTR18196049-01SMAD4 Antibody

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