ACK1 Antibody

• Background:

  ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

• NCBI Gene ID:

  10188

• Swiss Prot:

  Q07912

• Accession Number:

  Q07912

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-964 amino acids from the C-terminal region of human ACK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  115 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TNK2

• NCBI Official Name:

  Activated CDC42 kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yokoyama, N., et al., J. Biol. Chem. 278 (48) :47713-47723 (2003) .

• Background Reference 02:

  Manser, E., et al., Nature 363 (6427) :364-367 (1993) .

• Other Product Names:

  Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  229462980

• Physical Properties:

  Liquid