CD117 Antibody [ACK2] (APC)

• Background:

  The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.

• NCBI Gene ID:

  16590

• Swiss Prot:

  P05532

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  ACK2

• Conjugation:

  APC

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.

• Symbol:

  Kit

• NCBI Official Name:

  Kit oncogene

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Background Reference 02:

  Yarden, Y., Kuang, W. J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., ... Ullrich, A. (1987) . Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.The EMBO Journal,6 (11), 3341.

• Background Reference 03:

  Lerner, N. B., Nocka, K. H., Cole, S. R., Qiu, F. H., Strife, A., Ashman, L. K., Besmer, P. (1991) . Monoclonal antibody YB5. B8 identifies the human c-kit protein product.Blood,77 (9), 1876-1883.

• Other Product Names:

  W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, CD117, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, Kit

• Tested Applications:

  Flow

• Physical Properties:

  Liquid