RegisterLogin

ABL1 Antibody

CAT: 0223-63-153Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-153Size:400 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
NCBI Gene ID
25
Swiss Prot
P00519
Accession Number
P00519
Host
Rabbit
Reactivity
Human
Immunogen
This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
123 kDa
Fragment
Rabbit IgG
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ABL1
NCBI Official Name
Tyrosine-protein kinase ABL1
NCBI Organism
Homo sapiens
Background Reference 01
Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (22) :14053-14058 (2002) .
Background Reference 02
Pisabarro, M.T., et al., J. Mol. Biol. 281 (3) :513-521 (1998) .
Background Reference 03
Nam, H.J., et al., Structure 4 (9) :1105-1114 (1996) .
Background Reference 04
Chissoe, S.L., et al., Genomics 27 (1) :67-82 (1995) .
Other Product Names
Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7
Tested Applications
WB
Protein ID
85681908
Physical Properties
Liquid

Related Products

CatalogName
79-839ABL1 (phospho Thr735) Antibody
79-245ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
79-691ABL1 / 2 (Ab 393 / 429) Antibody
61-626ABL Antibody
32-104ABL2 Antibody [1H1B11]
63-152C ABL Antibody
99-112CD107b Antibody [ABL-93]
99-114CD107b Antibody [ABL-93] (APC)
99-113CD107b Antibody [ABL-93] (FITC)
64-160WAS Antibody

Alternative Products

CatalogName
MBS8582908-01ABL1 Antibody

Popular Products