ABL Antibody

• Background:

  ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.

• NCBI Gene ID:

  25

• Swiss Prot:

  P00519

• Accession Number:

  P00519

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  123 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ABL1

• NCBI Official Name:

  Tyrosine-protein kinase ABL1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cao, C., et al., Biochemistry 42 (35) :10348-10353 (2003) .

• Background Reference 02:

  Cao, C., et al., J. Biol. Chem. 278 (32) :29667-29675 (2003) .

• Background Reference 03:

  Kruh, G.D., et al., Proc. Natl. Acad. Sci. U.S.A. 87 (15) :5802-5806 (1990) .

• Background Reference 04:

  Kruh, G.D., et al., Science 234 (4783) :1545-1548 (1986) .

• Other Product Names:

  Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG

• Tested Applications:

  WB

• Protein ID:

  85681908

• Physical Properties:

  Liquid