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TEK Antibody

CAT: 0223-63-140Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-140Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
NCBI Gene ID
7010
Swiss Prot
Q02763
Accession Number
Q02763
Host
Rabbit
Reactivity
Human
Immunogen
This TEK (TIE2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 758-789 amino acids from the C-terminal region of human TEK (TIE2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
126 kDa
Fragment
Rabbit Ig
Symbol
TEK
NCBI Official Name
Angiopoietin-1 receptor
NCBI Organism
Homo sapiens
Background Reference 01
Cascone, I., et al., Blood 102 (7) :2482-2490 (2003) .
Background Reference 02
DeBusk, L.M., et al., Arthritis Rheum. 48 (9) :2461-2471 (2003) .
Background Reference 03
Poncet, S., et al., Neuropathol Appl Neurobiol 29 (4) :361-369 (2003) .
Background Reference 04
Lee, H.J., et al., Biochem. Biophys. Res. Commun. 304 (2) :399-404 (2003) .
Other Product Names
Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p140 TEK, CD202b, TEK, TIE2, VMCM, VMCM1
Tested Applications
WB, IHC-P
Protein ID
218511853
Physical Properties
Liquid

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