RON Antibody

• Background:

  Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families) .

• NCBI Gene ID:

  4486

• Swiss Prot:

  Q04912

• Accession Number:

  Q04912

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RON antibody is generated from rabbits immunized with two KLH conjugated synthetic peptides between 22-51 amino and 1370-1400 acids from the N-terminal and C-terminal regions of human RON.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  152 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MST1R

• NCBI Official Name:

  Macrophage-stimulating protein receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Maggiora, P., et al., Exp. Cell Res. 288 (2) :382-389 (2003) .

• Background Reference 02:

  Santoro, M.M., et al., Dev. Cell 5 (2) :257-271 (2003) .

• Background Reference 03:

  Penengo, L., et al., Oncogene 22 (24) :3669-3679 (2003) .

• Background Reference 04:

  Zhou, Y.Q., et al., Oncogene 22 (2) :186-197 (2003) .

• Other Product Names:

  Macrophage-stimulating protein receptor, MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R, PTK8, RON

• Tested Applications:

  WB

• Protein ID:

  294862462

• Physical Properties:

  Liquid