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RET Antibody

CAT: 0223-63-127Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-127Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
NCBI Gene ID
5979
Swiss Prot
P07949
Accession Number
P07949
Host
Rabbit
Reactivity
Human
Immunogen
This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1012-1042 amino acids from the C-terminal region of human RET.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
124 kDa
Fragment
Rabbit Ig
Symbol
RET
NCBI Official Name
Proto-oncogene tyrosine-protein kinase receptor Ret
NCBI Organism
Homo sapiens
Background Reference 01
Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88 (11) :5438-5443 (2003) .
Background Reference 02
McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88 (10) :4911-4916 (2003) .
Background Reference 03
D'Alessio, A., et al., Endocrinology 144 (10) :4298-4305 (2003) .
Background Reference 04
Soares, P., et al., Oncogene 22 (29) :4578-4580 (2003) .
Other Product Names
Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment, RET, CDHF12, CDHR16, PTC, RET51
Tested Applications
WB, IHC-P
Protein ID
547807
Physical Properties
Liquid

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