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MCK10 Antibody

CAT: 0223-63-112Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-112Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI) . In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
NCBI Gene ID
780
Swiss Prot
Q08345
Accession Number
Q08345
Host
Rabbit
Reactivity
Human
Immunogen
This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Symbol
DDR1
NCBI Official Name
Epithelial discoidin domain-containing receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Vogel, W., et al., Mol. Cell 1 (1) :13-23 (1997) .
Background Reference 02
Playford, M.P., et al., Genome Res. 6 (7) :620-627 (1996) .
Background Reference 03
Perez, J.L., et al., Oncogene 12 (7) :1469-1477 (1996) .
Background Reference 04
Valent, A., et al., Hum. Genet. 98 (1) :12-15 (1996) .
Other Product Names
Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD167a, DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Tested Applications
WB, IHC-P
Protein ID
729008
Physical Properties
Liquid

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