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CPE Antibody

CAT: 0223-63-109Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-109Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in CPE gene are implicated in type II diabetes.
NCBI Gene ID
1363
Swiss Prot
P16870
Accession Number
P16870
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human CPE.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CPE
NCBI Official Name
Carboxypeptidase E
NCBI Organism
Homo sapiens
Background Reference 01
Oiso, S., J. Neurochem. 109 (1), 158-167 (2009)
Background Reference 02
Yang, L., Ann. N. Y. Acad. Sci. 1150, 263-266 (2008)
Background Reference 03
Jeffrey, K.D., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8452-8457 (2008)
Other Product Names
Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE
Tested Applications
WB
Protein ID
115892
Physical Properties
Liquid

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