KDR Antibody

• Background :

  KDR is a major growth factor for endothelial cells. This protein encodes one of the two receptors of the KDR. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc..

• NCBI Gene ID :

  3791

• Swiss Prot :

  P35968

• Accession Number :

  P35968

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This KDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1153-1182 amino acids from human KDR.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Immunology, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  152 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  KDR

• NCBI Official Name :

  Vascular endothelial growth factor receptor 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Huang, D., et al. Cancer Res. 70 (3) :1053-1062 (2010)

• Background Reference 02 :

  Sentilhes, L., et al. J. Neuropathol. Exp. Neurol. 69 (2) :111-128 (2010)

• Background Reference 03 :

  Lamalice, L., et al. J. Biol. Chem. 281 (45) :34009-34020 (2006)

• Background Reference 04 :

  Meyer, R.D., et al. J. Biol. Chem. 277 (30) :27081-27087 (2002)

• Other Product Names :

  Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, KDR, Protein-tyrosine kinase receptor flk-1, CD309, KDR, FLK1, VEGFR2

• Tested Applications :

  WB, Flow

• Protein ID :

  9087218

• Physical Properties :

  Liquid