NAB2 Antibody

• Background :

  NAB2 is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by this protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex.

• NCBI Gene ID :

  4665

• Swiss Prot :

  Q15742

• Accession Number :

  Q15742

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This NAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human NAB2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  57 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  NAB2

• NCBI Official Name :

  NGFI-A-binding protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Srinivasan, R., J. Biol. Chem. 281 (22), 15129-15137 (2006)

• Background Reference 02 :

  Kumbrink, J., J. Biol. Chem. 280 (52), 42785-42793 (2005)

• Background Reference 03 :

  Lucerna, M., J. Biol. Chem. 278 (13), 11433-11440 (2003)

• Other Product Names :

  NGFI-A-binding protein 2, EGR-1-binding protein 2, Melanoma-associated delayed early response protein, Protein MADER, NAB2, MADER

• Tested Applications :

  WB

• Protein ID :

  12643729

• Physical Properties :

  Liquid