EGFR Antibody

• Background:

  The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4) . Mutations affecting EGFR expression or activity could result in cancer.

• NCBI Gene ID:

  1956

• Swiss Prot:

  P00533

• Accession Number:

  P00533

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1048-1077 amino acids from human EGFR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  134 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EGFR

• NCBI Official Name:

  Epidermal growth factor receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zanardi, T.A., et al., J. Virol. 77 (21) :11685-11696 (2003) .

• Background Reference 02:

  Krug, A.W., et al., J. Biol. Chem. 278 (44) :43060-43066 (2003) .

• Background Reference 03:

  Huang, F., et al., J. Biol. Chem. 278 (44) :43411-43417 (2003) .

• Background Reference 04:

  He, Y.Y., et al., J. Biol. Chem. 278 (43) :42457-42465 (2003) .

• Other Product Names:

  Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  2811086

• Physical Properties:

  Liquid