NCF4 Antibody

CAT: 0223-63-049Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-049Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI (3) kinase, which suggests its role in PI (3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity.
NCBI Gene ID
4689
Swiss Prot
Q15080
Accession Number
Q15080
Host
Rabbit
Reactivity
Human
Immunogen
This NCF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-289 amino acids from the C-terminal region of human NCF4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Symbol
NCF4
NCBI Official Name
Neutrophil cytosol factor 4
NCBI Organism
Homo sapiens
Background Reference 01
Glas, J., Seiderer, J. Am. J. Gastroenterol. 104 (3), 665-672 (2009)
Background Reference 02
Honbou, K. Seikagaku 80 (8), 743-747 (2008)
Background Reference 03
Dusi, S., Donini, M. Biochem. J. 314 (PT 2), 409-412 (1996)
Background Reference 04
Leto, T.L. Proc. Natl. Acad. Sci. U.S.A. 91 (22), 10650-10654 (1994)
Other Product Names
Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, SH3 and PX domain-containing protein 4, p40-phox, p40phox, NCF4, SH3PXD4
Tested Applications
WB, IHC-P, Flow
Protein ID
108884815
Physical Properties
Liquid

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