CLOCK Antibody

• Background:

  CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within this protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

• NCBI Gene ID:

  9575

• Swiss Prot:

  O15516

• Accession Number:

  O15516

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CLOCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-249 amino acids from the Central region of human CLOCK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  95 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CLOCK

• NCBI Official Name:

  Circadian locomoter output cycles protein kaput

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sookoian, S., Am. J. Clin. Nutr. 87 (6), 1606-1615 (2008)

• Background Reference 02:

  Nakashima, A., Mol. Cell. Biol. 28 (12), 4080-4092 (2008)

• Background Reference 03:

  Marino, J.L., Epidemiology 19 (3), 477-484 (2008)

• Other Product Names:

  Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8, CLOCK, BHLHE8, KIAA0334

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid