CUL5 Antibody

• Background:

  CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.

• NCBI Gene ID:

  8065

• Swiss Prot:

  Q93034

• Accession Number:

  Q93034

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CUL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 747-774 amino acids from the C-terminal region of human CUL5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rb

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  91 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CUL5

• NCBI Official Name:

  Cullin-5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kamura T., Burian D., Yan Q.J. Biol. Chem. 276:29748-29753 (2001)

• Background Reference 02:

  Mehle A., Goncalves J., Santa-Marta M.Genes Dev. 18:2861-2866 (2004)

• Background Reference 03:

  Kamura T., Maenaka K., Kotoshiba S.Genes Dev. 18:3055-3065 (2004)

• Other Product Names:

  Cullin-5, CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1, CUL5, VACM1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  14917099

• Physical Properties:

  Liquid