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P21 Antibody

CAT: 0223-62-967Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-967Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDKN1A is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. Expression is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.
NCBI Gene ID
1026
Swiss Prot
P38936
Accession Number
P38936
Host
Rabbit
Reactivity
Human
Immunogen
This p21 (CDKN1A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the C-terminal region of human p21 (CDKN1A) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Symbol
CDKN1A
NCBI Official Name
Cyclin-dependent kinase inhibitor 1
NCBI Organism
Homo sapiens
Background Reference 01
Fukuchi, K., et al., Biochim. Biophys. Acta 1642 (3) :163-171 (2003) .
Background Reference 02
Frouin, I., et al., J. Biol. Chem. 278 (41) :39265-39268 (2003) .
Background Reference 03
Dupont, J., et al., J. Biol. Chem. 278 (39) :37256-37264 (2003) .
Background Reference 04
Di Padova, M., et al., J. Biol. Chem. 278 (38) :36496-36504 (2003) .
Other Product Names
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
729143
Physical Properties
Liquid

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