GIPR Antibody

• Background:

  GIPR also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. This protein was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. The protein is involved in several other facets of the anabolic response.

• NCBI Gene ID:

  2696

• Swiss Prot:

  P48546

• Accession Number:

  P48546

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GIPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-136 amino acids from the Central region of human GIPR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GIPR

• NCBI Official Name:

  Gastric inhibitory polypeptide receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Herbach, N. Am. J. Physiol. Renal Physiol. 296 (4), F819-F829 (2009)

• Background Reference 02:

  Rudovich, N., Kaiser, S. Regul. Pept. 142 (3), 138-145 (2007)

• Background Reference 03:

  Nitz, I., Fisher, E. Mol Nutr Food Res 51 (8), 1046-1052 (2007)

• Other Product Names:

  Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor, GIPR

• Tested Applications:

  WB

• Protein ID:

  1346133

• Physical Properties:

  Liquid