BCOR Antibody

• Background:

  BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs.

• NCBI Gene ID:

  54880

• Swiss Prot:

  Q6W2J9

• Accession Number:

  Q6W2J9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1107-1137 amino acids from the Central region of human BCOR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  192 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BCOR

• NCBI Official Name:

  BCL-6 corepressor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ghetu, A.F., Mol. Cell 29 (3), 384-391 (2008)

• Background Reference 02:

  Hilton, E.N., Hum. Mol. Genet. 16 (14), 1773-1782 (2007)

• Other Product Names:

  BCL-6 corepressor, BCoR, BCOR, KIAA1575

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid