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MME Antibody

CAT: 0223-62-829Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-829Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
NCBI Gene ID
4311
Swiss Prot
P08473
Accession Number
P08473
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the Central region of human MME.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Symbol
MME
NCBI Official Name
Neprilysin
NCBI Organism
Homo sapiens
Background Reference 01
Dakka, N., Bellaoui, H. Pediatr Hematol Oncol 26 (4), 216-231 (2009)
Background Reference 02
Wang, R., Wang, S. J. Neurochem. 108 (4), 1072-1082 (2009)
Background Reference 03
Shipp, M.A. Proc. Natl. Acad. Sci. U.S.A. 88 (23), 10662-10666 (1991)
Background Reference 04
Shipp, M.A. Proc. Natl. Acad. Sci. U.S.A. 86 (1), 297-301 (1989)
Other Product Names
Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
Tested Applications
WB, IF
Protein ID
128062
Physical Properties
Liquid

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