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HYOU1 Antibody

CAT: 0223-62-818Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-818Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
NCBI Gene ID
10525
Swiss Prot
Q9Y4L1
Accession Number
Q9Y4L1
Host
Rabbit
Reactivity
Human
Immunogen
This HYOU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human HYOU1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
111 kDa
Fragment
Rabbit Ig
Symbol
HYOU1
NCBI Official Name
Hypoxia up-regulated protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Kitao, Y., Matsuyama, T. Antioxid. Redox Signal. (5), 589-595 (2007)
Background Reference 02
Bando, Y., Ogawa, S. Am. J. Physiol., Cell Physiol. 278 (6), C1172-C1182 (2000)
Other Product Names
Hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, ORP-150, 170 kDa glucose-regulated protein, GRP-170, HYOU1, GRP170, ORP150
Tested Applications
WB, IHC-P, IF
Protein ID
10720185
Physical Properties
Liquid

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