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CDKL5 Antibody

CAT: 0223-62-757Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-757Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.
NCBI Gene ID
6792
Swiss Prot
O76039
Accession Number
O76039
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
116 kDa
Fragment
Rabbit Ig
Symbol
CDKL5
NCBI Official Name
Cyclin-dependent kinase-like 5
NCBI Organism
Homo sapiens
Background Reference 01
Kalscheuer, V.M., et al., Am. J. Hum. Genet. 72 (6) :1401-1411 (2003) .
Background Reference 02
Montini, E., et al., Genomics 51 (3) :427-433 (1998) .
Other Product Names
Cyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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