CDKL5 Antibody

• Background:

  Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.

• NCBI Gene ID:

  6792

• Swiss Prot:

  O76039

• Accession Number:

  O76039

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  116 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDKL5

• NCBI Official Name:

  Cyclin-dependent kinase-like 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kalscheuer, V.M., et al., Am. J. Hum. Genet. 72 (6) :1401-1411 (2003) .

• Background Reference 02:

  Montini, E., et al., Genomics 51 (3) :427-433 (1998) .

• Other Product Names:

  Cyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid