AMHR2 Antibody

• Background:

  The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.

• NCBI Gene ID:

  269

• Swiss Prot:

  Q16671

• Accession Number:

  Q16671

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human AMHR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  63 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AMHR2

• NCBI Official Name:

  Anti-Muellerian hormone type-2 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Picard, J.Y., et al., J. Soc. Biol. 196 (3) :217-221 (2002) .

• Background Reference 02:

  Teixeira, J., et al., Endocr. Rev. 22 (5) :657-674 (2001) .

• Background Reference 03:

  Imbeaud, S., et al., Nat. Genet. 11 (4) :382-388 (1995) .

• Background Reference 04:

  Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215 (3) :1029-1036 (1995) .

• Other Product Names:

  Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII, AMHR2, AMHR, MISR2

• Tested Applications:

  WB

• Protein ID:

  9087133

• Physical Properties:

  Liquid