PKLR Antibody

CAT: 0223-62-615Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-615Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PKLR is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) .
NCBI Gene ID
5313
Swiss Prot
P30613
Accession Number
P30613
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PKLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-551 amino acids from the C-terminal region of human PKLR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Symbol
PKLR
NCBI Official Name
Pyruvate kinase PKLR
NCBI Organism
Homo sapiens
Background Reference 01
Wang, H., et al., Diabetes 51 (9) :2861-2865 (2002) .
Background Reference 02
Valentini, G., et al., J. Biol. Chem. 277 (26) :23807-23814 (2002) .
Background Reference 03
Mateu, E., et al., Hum. Genet. 110 (6) :532-544 (2002) .
Background Reference 04
Indo, Y., et al., Hum. Mutat. 18 (4) :308-318 (2001) .
Other Product Names
Pyruvate kinase PKLR, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, PKLR, PK1, PKL
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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