PKLR Antibody

• Background:

  PKLR is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) .

• NCBI Gene ID:

  5313

• Swiss Prot:

  P30613

• Accession Number:

  P30613

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PKLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-551 amino acids from the C-terminal region of human PKLR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PKLR

• NCBI Official Name:

  Pyruvate kinase PKLR

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang, H., et al., Diabetes 51 (9) :2861-2865 (2002) .

• Background Reference 02:

  Valentini, G., et al., J. Biol. Chem. 277 (26) :23807-23814 (2002) .

• Background Reference 03:

  Mateu, E., et al., Hum. Genet. 110 (6) :532-544 (2002) .

• Background Reference 04:

  Indo, Y., et al., Hum. Mutat. 18 (4) :308-318 (2001) .

• Other Product Names:

  Pyruvate kinase PKLR, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, PKLR, PK1, PKL

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid