ARGBP2 Antibody

• Background:

  Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. ARGBP2 is the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.

• NCBI Gene ID:

  8470

• Swiss Prot:

  O94875

• Accession Number:

  O94875

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARGBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-204 amino acids from the N-terminal region of human ARGBP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  124 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SORBS2

• NCBI Official Name:

  Sorbin and SH3 domain-containing protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yuan, Z.Q., et.al., J. Biol. Chem. 280 (22), 21483-21490 (2005)

• Background Reference 02:

  Olsen, J.V., et.al., Cell 127 (3), 635-648 (2006)

• Background Reference 03:

  Taieb, D., et.al., Cancer Res. 68 (12), 4588-4596 (2008)

• Other Product Names:

  Sorbin and SH3 domain-containing protein 2, Arg/Abl-interacting protein 2, ArgBP2, Sorbin, SORBS2, ARGBP2, KIAA0777

• Tested Applications:

  WB, IHC-P, IF, Flow

• Physical Properties:

  Liquid