CBFB Antibody

• Background :

  CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2) . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.

• NCBI Gene ID :

  865

• Swiss Prot :

  Q13951

• Accession Number :

  Q13951

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This CBFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human CBFB.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  22 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CBFB

• NCBI Official Name :

  Core-binding factor subunit beta

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Andersen, C.L., et.al., Br. J. Cancer 100 (3), 511-523 (2009)

• Other Product Names :

  Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, CBFB

• Tested Applications :

  WB, IHC-P, IF, Flow

• Protein ID :

  2498753

• Physical Properties :

  Liquid