MAPRE1 Antibody

• Background:

  The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.

• NCBI Gene ID:

  22919

• Swiss Prot:

  Q15691

• Accession Number:

  Q15691

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MAPRE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the N-terminal region of human MAPRE1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  30 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAPRE1

• NCBI Official Name:

  Microtubule-associated protein RP/EB family member 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jaulin, F., et al. J. Cell Biol. 190 (3) :443-460 (2010)

• Background Reference 02:

  Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 03:

  De Groot, C.O., et al. J. Biol. Chem. 285 (8) :5802-5814 (2010)

• Background Reference 04:

  Jiang, K., et al. EMBO Rep. 10 (8) :857-865 (2009)

• Other Product Names:

  Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  20138589

• Physical Properties:

  Liquid