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MAPRE1 Antibody / EB1

CAT: 0800-RQ8286Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8286Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Microtubule-associated protein RP/EB family member 1, also called End-binding protein 1 (EB1), is a protein that in humans is encoded by the MAPRE1 gene. The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, ELISA: 0.1-0.5 µg/mL
UniProt
Q15691
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An E.coli-derived human recombinant protein (A145-Y268) was used as the immunogen for the MAPRE1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the MAPRE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MAPRE1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MAPRE1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MAPRE1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat lung, 2) rat stomach and 3) mouse lung tissue lysate with MAPRE1 antibody. Predicted molecular weight ~30 kDa.

UniProtKB · Q15691

Microtubule-associated protein RP/EB family member 1

MARE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15691
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPRE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R6I7, E1P5M8, Q3KQS8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Cell cycleCell divisionMitosis

Cellular component

Cell membraneCytoplasmCytoskeletonGolgi apparatusMembraneMicrotubule
Product Datasheet
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