MLF1 Antibody

• Background :

  MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

• NCBI Gene ID :

  4291

• Swiss Prot :

  P58340

• Accession Number :

  P58340

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human MLF1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  31 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MLF1

• NCBI Official Name :

  Myeloid leukemia factor 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Li, Z.F., J. Neurol. Sci. 264 (1-2), 77-86 (2008)

• Background Reference 02 :

  Yoneda-Kato, N., EMBO J. 24 (9), 1739-1749 (2005)

• Other Product Names :

  Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  17368170

• Physical Properties :

  Liquid