XPO1 Antibody

• Background:

  XPO1 mediates leucine-rich nuclear export signal (NES) -dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

• NCBI Gene ID:

  7514

• Swiss Prot:

  O14980

• Accession Number:

  O14980

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This XPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-846 amino acids from the C-terminal region of human XPO1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  123 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  XPO1

• NCBI Official Name:

  Exportin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shen, A., Neurosurgery 65 (1), 153-159 (2009)

• Background Reference 02:

  Dong, X., Nat. Struct. Mol. Biol. 16 (5), 558-560 (2009)

• Other Product Names:

  Exportin-1, Exp1, Chromosome region maintenance 1 protein homolog, XPO1, CRM1

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid