GZMB Antibody

• Background:

  Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

• NCBI Gene ID:

  3002

• Swiss Prot:

  P10144

• Accession Number:

  P10144

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 amino acids from the C-terminal region of human GZMB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GZMB

• NCBI Official Name:

  Granzyme B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hagn, M., J. Immunol. 183 (3), 1838-1845 (2009)

• Background Reference 02:

  Gaafar, A., Exp. Hematol. 37 (7), 838-848 (2009)

• Background Reference 03:

  Girnita, D.M., Transplantation 87 (12), 1801-1806 (2009)

• Other Product Names:

  Granzyme B, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  317373361

• Physical Properties:

  Liquid