ALS2 Antibody

• Background :

  ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.

• NCBI Gene ID :

  57679

• Swiss Prot :

  Q96Q42

• Accession Number :

  Q96Q42

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1248-1277 amino acids from the C-terminal region of human ALS2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  184 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  ALS2

• NCBI Official Name :

  Alsin

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Soares, D.C., Mol Model 15 (2), 113-122 (2009)

• Background Reference 02 :

  Mintchev, N., Neurology 72 (1), 28-32 (2009)

• Other Product Names :

  Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, ALS2, ALS2CR6, KIAA1563

• Tested Applications :

  WB, IHC-P

• Protein ID :

  296434394

• Physical Properties :

  Liquid