Kallikrein 2 Antibody

• Background:

  Kallikreins are a group of serine proteases manifesting diverse physiological functions. The glandular kallikreins are a distinct group of serine proteases with an ability to release vasoactive peptides from kininogen in vitro, although the kininogenase activity of different kallikreins is highly variable. Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Many kallikrein genes are differentially expressed in various malignancies. Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer.

• NCBI Gene ID:

  3817

• Swiss Prot:

  P20151

• Accession Number:

  P20151

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Kallikrein 2 (KLK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-197 amino acids from the C-terminal region of human Kallikrein 2 (KLK2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KLK2

• NCBI Official Name:

  Kallikrein-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Haese, A., et al., Urol. 2005 Mar;173 (3) :752-6. Chiang, C.H., et al., Urol. 2005 Feb;173 (2) :429-32. Clements, J.A., et al., Crit Rev Clin Lab Sci. 2004;41 (3) :265-312. Borgono, C.A., et al., Mol Cancer Res. 2004 May;2 (5) :257-80. Yousef, G.M., Clin Biochem. 2003 Sep;36 (6) :443-52.

• Other Product Names:

  Kallikrein-2, Glandular kallikrein-1, hGK-1, Tissue kallikrein-2, KLK2

• Tested Applications:

  WB

• Protein ID:

  125174

• Physical Properties:

  Liquid