SPPL2a Antibody

• Background:

  By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.

• NCBI Gene ID:

  84888

• Swiss Prot:

  Q8TCT8

• Accession Number:

  Q8TCT8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SPPL2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the N-terminal region of human SPPL2a.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SPPL2A

• NCBI Official Name:

  Signal peptide peptidase-like 2A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Grigorenko, A. P., et al. Biochemistry 67: 826-834 (2002) .

• Other Product Names:

  Signal peptide peptidase-like 2A, SPP-like 2A, SPPL2a, 3423-, Intramembrane protease 3, IMP-3, Presenilin-like protein 2, SPPL2A, IMP3, PSL2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  25008981

• Physical Properties:

  Liquid