YBX1 Antibody

• Background:

  YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.

• NCBI Gene ID:

  4904

• Swiss Prot:

  P67809

• Accession Number:

  P67809

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-305 amino acids from the C-terminal region of human YBX1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  YBX1

• NCBI Official Name:

  Nuclease-sensitive element-binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fujii, T., Cancer Res. 68 (5), 1504-1512 (2008)

• Background Reference 02:

  Fraser, D.J., Kidney Int. 73 (6), 724-732 (2008)

• Background Reference 03:

  Shiota, M., Cancer Res. 68 (1), 98-105 (2008)

• Other Product Names:

  Nuclease-sensitive element-binding protein 1, CCAAT-binding transcription factor I subunit A, CBF-A, DNA-binding protein B, DBPB, Enhancer factor I subunit A, EFI-A, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, NSEP1, YB1

• Tested Applications:

  WB, IF

• Protein ID:

  54040031

• Physical Properties:

  Liquid