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VEGFB Antibody

CAT: 0223-62-228Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-228Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13.
NCBI Gene ID
7423
Swiss Prot
P49765
Accession Number
P49765
Host
Rabbit
Reactivity
Human
Immunogen
This VEGFB (VEGF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-139 amino acids from the Central region of human VEGFB (VEGF2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Symbol
VEGFB
NCBI Official Name
Vascular endothelial growth factor B
NCBI Organism
Homo sapiens
Background Reference 01
Trompezinski, S., et al., Exp. Dermatol. 13 (2) :98-105 (2004) .
Background Reference 02
Qi, J.H., et al., Nat. Med. 9 (4) :407-415 (2003) .
Background Reference 03
Joukov, V., et al., J. Cell. Physiol. 173 (2) :211-215 (1997) .
Background Reference 04
Olofsson, B., et al., J. Biol. Chem. 271 (32) :19310-19317 (1996) .
Other Product Names
Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF, VEGFB, VRF
Tested Applications
WB, IHC-P
Protein ID
17380554
Physical Properties
Liquid

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