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VEGFA Antibody

CAT: 0223-56-265Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-265Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
NCBI Gene ID
7422
Swiss Prot
P15692
Accession Number
P15692
Host
Rabbit
Reactivity
Human
Immunogen
This VEGFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the Central region of human VEGFA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
VEGFA
NCBI Official Name
Vascular endothelial growth factor A
NCBI Organism
Homo sapiens
Background Reference 01
Shrivastava-Ranjan, P., et al. J. Virol. 84 (21) :11227-11234 (2010)
Background Reference 02
Kim, Y.H., et al. Gynecol. Oncol. 119 (2) :232-236 (2010)
Background Reference 03
Yang, Y., et al. Exp. Biol. Med. (Maywood) 235 (10) :1204-1211 (2010)
Background Reference 04
Huez, I., et al. Mol. Endocrinol. 15 (12) :2197-2210 (2001)
Other Product Names
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF
Tested Applications
WB
Protein ID
17380528
Physical Properties
Liquid

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