VEGFA Antibody

• Background:

  This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

• NCBI Gene ID:

  7422

• Swiss Prot:

  P15692

• Accession Number:

  P15692

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This VEGFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the Central region of human VEGFA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  27 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  VEGFA

• NCBI Official Name:

  Vascular endothelial growth factor A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shrivastava-Ranjan, P., et al. J. Virol. 84 (21) :11227-11234 (2010)

• Background Reference 02:

  Kim, Y.H., et al. Gynecol. Oncol. 119 (2) :232-236 (2010)

• Background Reference 03:

  Yang, Y., et al. Exp. Biol. Med. (Maywood) 235 (10) :1204-1211 (2010)

• Background Reference 04:

  Huez, I., et al. Mol. Endocrinol. 15 (12) :2197-2210 (2001)

• Other Product Names:

  Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF

• Tested Applications:

  WB

• Protein ID:

  17380528

• Physical Properties:

  Liquid