ATF4 Antibody

• Background:

  ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . ATF4 belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain.

• NCBI Gene ID:

  468

• Swiss Prot:

  Q96AQ3

• Accession Number:

  Q96AQ3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-252 amino acids from human ATF4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ATF4

• NCBI Official Name:

  ATF4 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gombart, A.F., J. Leukoc. Biol. 81 (6), 1535-1547 (2007)

• Background Reference 02:

  Jousse, C., J. Biol. Chem. 282 (21), 15851-15861 (2007)

• Background Reference 03:

  Kakiuchi, C., Neurosci. Lett. 417 (3), 316-321 (2007)

• Background Reference 04:

  Marchand, A., J. Biol. Chem. 281 (28), 19124-19133 (2006)

• Other Product Names:

  Tax-responsive enhancer element B67; ATF4 protein

• Tested Applications:

  WB

• Physical Properties:

  Liquid