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27Kip1 Antibody

CAT: 0223-62-207Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-207Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
NCBI Gene ID
1027
Swiss Prot
P46527
Accession Number
P46527
Host
Rabbit
Reactivity
Human
Immunogen
This 27Kip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the C-terminal region of human 27Kip1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Hamster
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Symbol
CDKN1B
NCBI Official Name
Cyclin-dependent kinase inhibitor 1B
NCBI Organism
Homo sapiens
Background Reference 01
Kawamata, N., et al., Eur. J. Haematol. 74 (5) :424-429 (2005) .
Background Reference 02
Andreu, E.J., et al., Cancer Res. 65 (8) :3264-3272 (2005) .
Background Reference 03
Wingate, H., et al., J. Biol. Chem. 280 (15) :15148-15157 (2005) .
Background Reference 04
Wang, C., et al., J. Biol. Chem. 280 (13) :12339-12343 (2005) .
Other Product Names
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
Tested Applications
WB, IF
Physical Properties
Liquid

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