M Sirt3 Antibody

• Background:

  SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.

• NCBI Gene ID:

  64384

• Swiss Prot:

  Q8R104

• Accession Number:

  Q8R104

• Host:

  Rabbit

• Reactivity:

  Mouse, Hamster

• Immunogen:

  This Sirt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-334 amino acids from the C-terminal region of Mouse Sirt3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Sirt3

• NCBI Official Name:

  NAD-dependent protein deacetylase sirtuin-3

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Hirschey, M.D., et al. Nature 464 (7285) :121-125 (2010)

• Background Reference 02:

  Pillai, V.B., et al. J. Biol. Chem. 285 (5) :3133-3144 (2010)

• Background Reference 03:

  Kim, H.S., et al. Cancer Cell 17 (1) :41-52 (2010)

• Other Product Names:

  NAD-dependent protein deacetylase sirtuin-3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, mSIR2L3, Sirt3, Sir2l3

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid