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SIRT3 Antibody

CAT: 0223-5767-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5767-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SIRT3 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence, lifespan extension and several age-related diseases. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death.
NCBI Gene ID
23410
Swiss Prot
Q9NTG7
Accession Number
NP_036371
Host
Chicken
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SIRT3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1401 - Mouse Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
SIRT3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SIRT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgY
Symbol
SIRT3
NCBI Official Name
Sirtuin 3
NCBI Organism
Homo sapiens
Background Reference 01
Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.
Background Reference 02
Lavu S, Boss O, Elliott PJ, et al. Sirtuins - novel therapeutic targets to treat age-associated diseases. Nat. Rev. Drug. Disc.2008; 7:841-53.
Background Reference 03
Onyango P, Celic I, McCaffery JM, et al. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc. Natl. Acad. Sci. USA.2002; 99:13653-8.
Background Reference 04
Hirschey MD, Shimazu T, Goetzman E, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature2010; 464:121-5.
Other Product Names
SIRT3 Antibody: SIR2L3, SIR2L3, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Regulatory protein SIR2 homolog 3, hSIRT3
Tested Applications
ELISA, WB
Protein ID
6912660
Physical Properties
Liquid

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